Research & Training

Samples in the lab being handled.

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Researcher working with samples in the lab.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

LSI researchers walking and talking.

Recent Publications

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Structural enzymology of a Fusarium graminearum aldehyde oxidase reveals a distinct active-site and reactivity versus its paralog galactose oxidase

Researcher: Van Petegem

CSF1R+ macrophage and osteoclast depletion impairs neural crest proliferation and craniofacial morphogenesis

Researcher: Rosin

Hybrid Lipid Nanoparticles Containing Iron Oxide Nanoparticles and Doxorubicin

Researcher: Cullis

Characterization of acetovanillone degradation in wild-type and engineered Rhodococcus aromaticivorans RHA1

Researcher: Eltis

Role of the anti-Shine-Dalgarno sequence of 16S rRNA in Flavobacterium johnsoniae

Researcher: Foster

Uniform bacterial genetic diversity along the gut

Researcher: Tropini

Interactions between immuno-epidemiology and individual decision-making for nonpharmaceutical interventions

Researcher: Abraham

ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition

Researcher: Kieffer

Simulated microgravity models sex differences in knee osteoarthritis through a CD36-regulated mechano-metabolic circuit

Researcher: Graf

The subiculum: cell-type-specific composition, computation, and function

Researcher: Cembrowski

Towards large-scale mass spectrometry-based omics for clinical applications

Researcher: Foster

SPIN: Inkjet-Driven Nanowell Workflow for Scalable and Sensitive Single-Cell Proteomics

Researchers: Foster, Cheung

Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases

Researcher: J Johson

Structural insights into insect-selective sodium channel toxins drive AI-enhanced biopesticide design

Researcher: Van Petegem

Impact of adverse postnatal environment on emotional regulation and neuroimmune function in adolescent rats prenatally exposed to alcohol

Researcher: Weinberg